The objective of this research is to find out the influence of leadership, compensation, and work motivation both partially and simultaneously onthe nurses Performance.The methods used are descriptive surveyand explanatory survey method. The populations are the nurses from 61 pribate Clinical medicine institution of West Java Province with 245 respondents as the samples. The data analysis method used is SEM (Structural Equation Modeling). The findings show that leadership and compensation positively and significantly influence on work motivation, both partially and simultaneously. Partially, the compensation is the most dominant variable to influence the work motivation. Leadership, compensation, and work motivation, both partially and simultaneously have a positive and significant contribution on nurse performance. Partially, work motivation is the most dominant variable to influence nurse performance. Work motivation is the most dominant variable influences the which the nurse performance. The finding Also shows that work motivation is the full mediating variable on the influence of leadership and compensation toward nurse performance. This research recommends to improve the performance of the nurses of private Clinical medicine institution in Districts / Cities of West Java Province.