Background: The present study was conducted to determine the level of salivary cytokines in the absence or presence of periodontal and peri-implant maintenance therapy (TMPP).Materials & Methods: 48 patients with signs of peri implant mucositis and peri- implantitis were divided into 2 groups. Group I that performed TMPP regularly (GTP=24) and group II did not perform TMPP regularly, (GNTP=24). Cytokines such as IL-1β, IL-10, MMP-2, RANK, TGF-β and TNF-α were determined using diagnostic kit. Results: There was non- significant difference in salivary biomarkers level between T1 and T2 in patients with peri implant mucositis and peri- implantitis (P> 0.05). There was nonsignificant difference (P> 0.05) in concentration of IL- I β, IL- 10, TGF- β, MMP- 2 and RANK between MP and PI patients in both GNTP and GTP group whereas TNF- a showed significant difference between MP and PI patients in GNTP group (P< 0.05). Conclusion: The level of tumor necrotic factor alpha was higher in patients with periimplantitis in patients with GNTP as compared to other cytokines.