ABSTRACT: Background: During the last century, there has been a high increase in health problems in the world, including Indonesia, one of it is mental health. The actual prevalence of mental health disorders worldwide remains poorly understood. Mental health is very much underreported, and under-diagnosed. Aims The purpose of this study was to identify factors associated with schizophrenia relapse of patients at the Islamic Mental Hospital in Jakarta, Indonesia. Settings and Design The research method with a quantitative approach was performed with a total sample comprisedof 150 respondents using primary data. Material and Methods The data collection method used was library research, field research (observation), and questionnaire research design through a cross-sectional approach. Statistical Analysis Univariate analysis process (frequency distribution) and Bivariate analysis with the Chisquare test and multi-variate with path analysis was used in this study Results Based on the results of the validity of the instrument, the variable of compliance for taking medication (X1), Stress variable (X2), Drug Abuse variable (X3), the Psychology variable (X4), the variable of Emotional Expression (X5), Relapse among schizophrenic patients (Y) was considered. The results revealed that the correlation of the adherence to the antipsychotic drugs consumption (X1), stress level (X2), and psychological response (X4) to the relapse in schizophrenia patients (Z) is acceptable, whereas the strongest or dominant correlation is the stress factor (X2). Conclusions The results of this study can provide a plan for schizophrenic patients in the country. Since schizophrenic patients need medication and treatment for a long time, the researchers recommend for the government to provide medical assistance.