ABSTRACT: The study of the adrenaline content in the blood and the manifestation of a stress state in patients using psychoactive substances (PAS) with HIV infection is one of the key indicators in the provision of medical and psychological assistance and the development of appropriate psychotherapeutic measures. When carrying out these activities, it is necessary to take into account the level of adrenaline and the severity of stressful conditions, in order to be able to overcome stress and adapt to the diagnosis.