Amiodarone HCl is an against of arrhythmic medication. This prescription is utilized to treat specific sorts of genuine (potentially deadly) unpredictable heartbeat, (for example, determined ventricular fibrillation/tachycardia). It is utilized to reestablish typical heart cadence and keep an ordinary, consistent heartbeat. Co precious stones is an elective methodology dependent on gem designing to upgrade explicit physicochemical and biopharmaceutical properties of dynamic drug fixings (APIs) when the ways to deal with salt or polymorph arrangement don't meet the normal targets. A precious stone designing methodology was utilized to configuration; build up a Co gem of the API. Co precious stones are strong substances, which comprise of not many segments combined. Co gems are multi segment frameworks in which two parts, a functioning drug fixing and a co previous were available in stoichiometric proportion and fortified along with non-covalent associations or Hydrogen holding in the precious stone cross section. There are a great deal of methods of co precious stones creation and application. The goal of the current work was centered around the improvement of watery solvency of medication by figuring Co-precious stone of Amiodarone HCl.