Epileptic seizures often cause transient impairment of consciousness, leaving the individual at risk of bodily harm. Therapy is symptomatic to which available drugs inhibit seizures. Phenobarbital exerts maximal antiseizure action at doses below those required for hypnosis. Phenobarbital is slowly absorbed from oral route, onset of action occurs within 30-60 mins, duration of action persist for 12-16 hours, 20-45% bound to plasma protein and only partly metabolized in the liver. Mouth dissolving films of phenobarbital can be used for emergency treatment of status epilepticus (SE) in all class of patients without need of trained persons. In the present work, an approach to develop and evaluate quick disintegrating films of Phenobarbital. Suitable film formers and plasticizers were selected based on optimization studies. Effect of superdisintegrants in formulation of mouth dissolving films at different concentrations has been investigated. Films were prepared by solvent casting method. The prepared films were evaluated for physicochemical parameters, in vitro disintegration & dissolution time, in vitro release rate study and stability study. The best formulation was found to be F3 showing 96.57 % drug release in 14 min, following first order kinetics. X-Ray diffraction studies show change in crystalline nature of drug in formulation