Introduction: COVID-19 Pandemic was supposedly one of the deadliest events in the 21st century which has caused immense strain on the healthcare and human resource. Globally this has caused 450 million of infective cases and over 6 million deaths till now. Studies have shown that ABO polymorphism plays a vital role in occurrence of various communicable and non-communicable diseases. ABO polymorphism was also considered to play a significant role in susceptibility and progression of SARS-CoV-2 infection by various studies. Though the results are not equivocal, globally researchers are interested in identifying the trend of infection and severity of illness among particular blood groups which could be helpful in framing certain prognostic markers for the COVID 19 disease and also can aid the researchers in inventing the vaccines and the novel therapies in curing the COVID 19 disease. This can also lay the foundation for some genomic studies which can link certain blood groups with certain novel diseases in the era of biological warfare.