ABSTRACT Chronic renal failure has become a very important health care modality in recent times and the incidence is already increasing mainly in the industrialized areas where physical, social, environmental, dietary factors play a major role. Renal failure as a disease shows different oral manifestations at different stages of the disease. This article is a review of the several factors in management of a dental patient with chronic renal failure (CRF), End Stage Renal Disease (ESRD).