: Asthma is a condition where a person’s airways became inflamed, narrow and swell and produce extra mucus which makes the person difficult to breath. There are some drugs used as a controller medicine for asthma. In this work, topological indices are used to determine the physical and chemical characteristics of asthma drugs. In the pandemic situation most of the people are dying from Covid-19 who were suffering from BP, Diabetes and Respiratory related (asthma) problems. This may help the chemists to understand the characteristics of drugs used in the treatment of asthma along with Covid-19.