To determine various factors contributing to the complication related to CT guided lung biopsy. MATERIALS & METHODS: A cross-sectional study was conducted between September 2020 to October 2021. Total of 34 patients who had suspected radiological lung masses were included in the study. Histological sample were collected through co-axial system of core needle biopsy. Various factors affecting complication was assessed against patient showing complication.RESULTS:Total of 6 (17.65%) post-procedural complications were noted in study which include pneumothorax and lung contusion. Multiple risk factors affecting the rate of complication were considered like predisposed emphysema, depth of the lesion, angle of insertion of biopsy needle, gauze size of the needle used and repeatability of the procedure. “Depth of the lesion” was best predictor of complications at cut-off point of >1.1 cm. CONCLUSION: This study is an attempt to evaluate the factors contributing to the safety and complications of core needle CT guided lung biopsy. One must should keep in mind these factors to procure uncomplicated procedure.