Introduction: Fever is the most frequent reason for hospital visit by the children. Paediatricians need markers, especially which increases early, to identify children at risk of severe bacterial infection. CRP and Interleukin -6 are such markers. Interleukin-6 is reported to rise earlier than CRP in children with fever. Objective: To study the level and correlation of Interleukin-6 and C-reactive protein in children presenting with febrile illness Study Design: Cross Sectional and descriptive study. Methods: 45 children with history of fever within last 72 hours were enrolled. Immuno-compromised patient were excluded from the study. Serum levels of CRP and IL-6 were analyzed along with haematological parameters. Microsoft SPSS version 20 was used for data analysis. P- value less than 0.05 was considered as significant. Results: Mean CRP value was 4.2±0.9mg/dl. Mean interleukin-6 was 60.5±10.9pg/ml. Interleukin-6 was found to be positively correlated with CRP (r=0.644). This correlation was found to be statistically significant.