In Premenopausal women the levels of reproductive hormones are variable and the effects of hormonal withdrawal are present and they may have menstrual cycles which may be regular or irregular. Perimenopause or menstrual transition is the period preceding the menopause characterized by irregular menses and missed cycles which is associated with increase in follicle stimulating hormone levels (> 20 IU/mL). The clinical data pertaining to all patients were recorded as per proforma. A detailed history was taken pertaining to last menstrual period, year of menopause, history of diabetes mellitus, hypertension, cardiac events, and drug intake. The study showed the positive correlation of plasma homocysteine with TC, LDL, VLDL, TG in postmenopausal and premenopausal women and negative correlation of plasma homocysteine with HDL.