Background: Stroke is the second leading cause of death in the world in the last two decades. The present study was conducted to evaluate correlation of HbA1C with lipid profile in patients of ischemic stroke or TIA. Materials & Methods: 50 patients of acute ischemic stroke or TIA, were assessed for glycosylated blood glucose and lipid profile level. Results: There were 10 patients in age group of <50years, 6 patients in age group of 50-60 years, 16 patients in age group 60-70 years, 11 patient in age group of 70-80 years and 7 patients in age group >80 years. The mean FBS (mg/dl) in group I was 96.6, in group II was 116 and in (%) group III was 163, RBS (mg/dl) was 132.1, 157 and 205.6 in group I, II and III respectively, HbA1C (%) was 5.3, 6.15 and 8.43, mean cholesterol level (mg/dl) was 148.6, 151.1 and 220.5, LDL (mg/dl) was 91.6, 97.5 and 154.21, HDL (mg/dl) was 41, 39.8 and 37.6, TG (mg/dl) was 106.9, 192.2 and 175.5 in group I, II and III respectively. The difference was significant (P< 0.05). Conclusion: HbA1C can be helpful in the management and outcome of patients of ischemic stroke and TIA.