Background: Human Immunodeficiency Virus (HIV) is an RNA virus that causes a decrease in the immune system and destroys specific white blood cells called Thelper lymphocytes or Cluster of Differentiation 4 (CD4); CD4 is a parameter in HIVAIDS patients while NLR is a simple parameters that were used to assess inflammatory status. Purpose: This study aims to determine the relationship between CD4 and NLR levels in HIV-AIDS patients. Methods: This is an observational study with a cross-sectional design conducted in September 2019-September 2020. The study populations were all HIV patients that hospitalized and outpatient at Dr. Wahidin Sudirohusodo Hospital and his network hospital. Data were analyzed descriptively to found out the association between CD4 and NLR levels in HIV-AIDS patients using the Spearman trial Results: A total of 150 subjects, consist of 62 (41.3%) subjects at age 30-39 years, 122 (81.3%) male subjects, 108 (72%) subjects who had PEM nutritional status, and 102 subjects (68%) subject with CD4 count <50. Based on the Spearman test, there is negative correlation of CD4 and NLR in HIV-AIDS patient. Conclusion: There are significant negative correlation between CD4 and NLR in HIVAIDS patients at Dr. Wahidin Sudirohusodo Makassar, which higher NLR correlates with the lower value of CD4..