Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Ductal hyperkeratinization, increased secretion of sebum, and colonization of Propionibacterium Acnes (P. acnes) around the pilosebaceous gland are among the factors responsible for the etiopathogenesis of acne vulgaris. Interleukin- (IL-) 19 is a cytokine expressed by epithelial cells with proinflammatory stimulation. A distinctive feature of IL19 is their ability of giving positive feedback loop to amplify themselves; once they are activated in inflammatory process, they will continuously produce the cytokine. The study aimed to identify the relation between blood levels of IL-19 and acne vulgaris. Methods: 36 acne patients and 12 healthy subjects were included in our study. All of patients and controls were subjected to full history, full general and dermatological examination. Serum IL-19 level was measured from each subject using quantitative sandwich enzyme-linked immunosorbent assay (ELISA) serum kits. Results: There was no statistical significance difference between the cases and controls in age and sex.Serum Interleukin 19 level is highly significant increased in patients with acne compared to controls. Serum IL-19 level was statistically significant with age of patients, disease duration and site of lesion. Conclusion: Interleukin 19 is higher in acne compared to controls. level of IL-19 positively correlated with age of patients and disease duration, that was statistically significantز