INTRODUCTION: Lung cancer is a leading cause of cancer-related deaths globally. Histopathological diagnosis is crucial for appropriate management of lung lesions detected by CT imaging. CT-guided Tru-cut biopsy is a highly accurate and sensitive diagnostic procedure in thoracic malignancy. The aim of this study was to investigate the correlation between the radiological features of lung masses and histopathological outcomes and to evaluate the usefulness of Trucut biopsy as an analytical strategy in lung tumors. METHODS: A cross-sectional study was conducted at Yenepoya Medical College Hospital, Mangalore, from July 2020 to January 2023. All patients diagnosed with a lung mass on CT imaging who underwent CT-guided biopsy were identified using complete enumeration. Histopathological reports of the biopsy specimens were obtained from the Department of Pathology. The provisional diagnosis given by the radiologists based on the CT findings was noted and correlation with the histopathological study was done using Fischer’s exact test. RESULTS: 29 patients were included in the study. The mean age was 58 years and male patients were more common than female patients (82.8% vs. 17.2%). Most patients (86%) had only one lesion and the majority of the lesions were located in the upper lobes of the lungs (37.9% on the right and 20.7% on the left). The shape of the lesions was lobulated in 79.3% of cases, while the margins were spiculated in 72.4% of cases. Heterogeneous enhancement was seen in 89.7% of cases. Other positive findings associated with the lesions included cavitations (6.9%), calcification (10.3%), lymphadenopathy (62.1%), pleural effusion (31.0%), lung collapse (27.6%), mediastinal involvement (24.1%) and chest wall invasion (17.2%). Histopathological analysis revealed that 86.2% of the cases were malignant while 13.8% were benign