Abstract. In this article author is tried to show explicit cooperation of the Republic of Uzbekistan and the United States of America in field of providing security in the region of Central Asia. Besides, in the article is given information the role of the Republic of Uzbekistan in the sphere of maintaining stable situation in the region and assistance of the USA. The article includes itself also information of modern policy of the Republic of Uzbekistan towards the Islamic Republic of Afghanistan and further proposals to provide its stable situation.