Invasive mycoses is fungal infection in the blood, normal sterile body fluids, deep tissue, and organ. Concomitant invasive mycoses and bacterial infection of the central nervous system are relatively rare. We describe a case of a 32-year-old female patient who presented seizure and decreased consciousness. Diagnosis of encephalitis was made base on the fulfillment of major (required) and minor criteria. From the clinical examination, there was no sign of neck stiffness. Laboratory results were suggested Cryptococcus sp based on cerebrospinal fluid analysis, and Candida tropicalis, and Streptococcus sp αhemolytic group based on cerebrospinal fluid culture. Whereas CT-scan showed brain edema.