Objective: The objective of the study was to compare the effectiveness of Isometric neck strengthening exercises with static stretching vs. static stretching alone in the management of nonspecific chronic neck pain. Methods: This was a randomized controlled trial study conducted in the Department of Physical Medicine and Rehabilitation, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India for 18 Months. Total 120 patients with nonspecific chronic neck pain were randomly assigned through simple random sampling technique, into experimental (group 1) received Isometric training with static stretching and control group (group 2) received Static stretching alone. While aerobic training was initiated in both groups prior to main interventions application. Therapeutic session was 4 days per week for 1 month. Neck pain and Disability was assessed by using outcome measures, numeric pain rating scale (NPRS) and neck disability index (NDI) on initial and final sessions. Results: Majority of chronic neck pain patients were above 40 years of age group. In experimental group at baseline mean NDI score 35.71±12.21 while after one month follow up after applying the Isometric strengthening exercises with static stretching exercises the total mean score was 22.94±18.16 which was significantly (p<0.001)12.77 mean point reduced in experimental group . In control group at baseline mean NDI score 31.24±11.12 while at one month follow up after applying static stretching exercises, the total mean score was 28.89±10.69which was significantly (p=0.002) 2.35 mean point reduced NDI mean score in control group. In experimental group at baseline mean NPRS score 6.23±1.51while after one month follow up after applying the Isometric strengthening exercises with static stretching exercises the total mean score was 3.11±1.59 which was significantly (p<0.001) 3.13 mean point reduced in experimental group. In control group at baseline mean NPRS score 5.49±1.71while at one month follow up after applying static stretching exercises, the total mean score was 4.38±1.92 which was significantly (p=0.001) 1.11 mean point reduced in control group. The total mean NDI score was 35.71± 12.21in experimental group and 31.24±11.12in control group respectively at baseline which was mean statistically insignificant (p=0.278). Conclusion: We concluded that the Isometric strengthening exercises training with static stretching appears more valuable as compared with static stretching training alone.