Objectives: The study compared the onset of sensory/motor blockade, as well as the postoperative analgesic efficacy of dexmedetomidine and Ropivacaine for brachial plexus blockade (0.75%). Methods: The study was a single-center, prospective, randomised experiment in which patients were randomly assigned to one of two groups conducted at SVBP Hospital, which is affiliated with LLRM Medical College in Meerut. The study was done in 40 patients undergoing various elective forearm procedures under brachial plexus block via supraclavicular route. Results: Mean sensory onset time was 7.25 ± 5.95 min in group A and 8 ± 5.71 min in group B. Mean onset time of motor block was 18.5 ± 5.15 min in group A and 14.5 ± 5.35 min in group B. Mean duration of analgesia in group A was 10.3 ± 2.93 min and in group B was 15.4 ± 5.44 min with statistically significant difference.. Conclusion: Block with a low dose of dexmedetomidine, i.e. 25µg, can be considered a better combination because the onset of sensory block was equally fast and acceptable, while the duration of analgesia was significantly low (p=0.0007) but acceptable, with the added benefit of a lower incidence of hypotension, bradycardia, and nausea than with 50µg (Group B).