Background: To compare the safety &Efficacy of topical Quick penetrating solution of Heparin 1000 IU/ml to Heparin gel 200 IU/g in the management of post infusion superficial thrombophlebitis. Method: 100 Patients aged 18-60 years having grade 2-4 superficial thrombophlebitis based on phlebitis scale were randomized to receive either Heparin QPS 1000 IU/ml or Heparin gel 200 IU/g. It was applied over the phlebitis lesion 3 TDS×7days. Length of venous lesion graded as per “Standards for Infusion Therapy” phlebitic scale& Local symptoms graded on 4 point severity scale. Change in venous lesion and local symptoms were assessed on day 3 and complete healing on day 7. Global assessment by patient done at the end of study. Results: 3rd day change in the length of venous lesion with Heparin QPS(16.44±8.54)to heparin gel(21.26±11.25),(P=0.0177)Change in local symptoms, fall in tenderness(p-0.0065) & raised local temperature(p-0.0029) with QPS. Complete healing on day 7 was found to be 90% compared to 58% with heparin QPS to gel(P<0.001) Also significant fall in percentage of patients with grade 2&3 were reported in those treated with QPS to gel(p=0.017)Most of the patients graderd Heparin QPS excellent(p<0.0001). Conclusions: Heparin QPS was found to be more effective in the treatment of post infusion superficial thrombophlebitis expressed by complete healing of the venous lesion as compared to heparin gel. Significant reduction in length of venous lesion from baseline, with fall in percentage of patients with grade 2&3,fall in local symptom scores on day 3.Significant proportion of patients completed healing on day 7.