Abstract: Backround: Lip-split incision has been traditionally used to manage the primary oral cavity tumour to ascertain clear surgical margins. Small tumour excision is routinely carried out per orally; however, there is a paucity of data vis-à-vis with the oncological safety of per oral approach in T2/T3 excision of oral squamous cell carcinoma (OSCC). Objective of the study: We compared per oral access over the transoral access in terms of assessing the tumour free surgical margins. Settings & Design: A prospective, interventional, double-blind, randomized control study was conducted among 20 histopathologically proven participants with previously untreated OSCC scheduled for curative intent. Subjects & Method: Participants were randomly allocated to the two intervention used. The primary outcome variables evaluated were the adequacy of the surgical margin. Additionally, the primary tumour resection time between two interventions was assessed. Results: The primary tumour resection time will be significantly extended in Peroral access & no significant difference will be seen pertaining to the adequacy of a safe surgical margin between two intervention. Peroral access will be a choice of surgical approaches that preserve function, minimize complications and maximize cosmetic outcome. Conclusion: Surgical approaches that minimalize complications, preserve function with the optimal cosmetic outcome should be utilized whenever feasible. Peroral access may offer significant advantages like avoiding transoral trauma, fastens the healing time & affords better & faster recovery.