Online ISSN: 2515-8260

Comparison Of Platelet Indices and Coagulation Profile in Preeclamptic/ Eclamptic with Normotensive Pregnant Females

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Dr. Deepti Agarwal1 , Dr. Preeti2 *, Dr. Rajiv Mahendru3 , Dr. Monika B Gathwal4 , Dr. Swaran Kaur Saluja5

Abstract

Background: Hypertensive disorders are the most common medical complications of pregnancy. Due to low socioeconomic status, poor health education and lack of regular antenatal supervision, the incidence of preeclampsia is more in developing countries like India. Pregnancy induced hypertension is an important health issue that has to be dealt especially in the developing countries. It is a hypertensive disorder which usually appears after the 20th week of gestation. Methods: The prospective case control study was conducted In Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat for the duration of one year from February 2021 to February 2022 on 110 pregnant women, 55 normotensive and 55 with PIH. The study parameters included Platelet count, Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT), thrombin time(TT), serum fibrinogen, D-dimer, protein C and protein S. Results: Platelet count decreased in pre-eclampsia but had no significant difference when compared to normotensive women. Mean platelet volume, Platelet distribution width, Serum fibrinogen, Ddimer showed significant difference in pre-eclamptic patients. Protein C was found within normal range. Protein S found marginally deranged in pre eclamptic women. Conclusion: Thus, authors came to the conclusion that platelet indices and coagulation profile can be used as a reliable early indicator of onset and severity of preeclampsia and eclampsia.

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