Background: In coronary artery disease (CAD) a mismatch exists between myocardial oxygen consumption and supply. Anesthetic goal targets balance between this supply and demand perioperatively for improved tissue perfusion. Studies show high thoracic epidural anesthesia (HTEA) helps to achieve this goal. Aims and Objective: To find out the effectiveness of HTEA in achieving improved tissue perfusion as measured by mixed venous oxygen saturation (SvO2) in patients undergoing coronary artery bypass grafting (CABG). Design of Study: Randomized control study Material and Method: Prospective randomized control study, where patients undergoing CABG were randomized into 2 groups; Group A: general anesthesia with HTEA and Group B: general anesthesia with conventional opioids. The objectives were to compare SvO2, heart rate (HR), blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP)], pulmonary artery wedge pressure (PWAP) and blood lactate levels. Sample size: Sample size was calculated to be 14, seven in each group using WinPepi software. For better evaluation of results, we have taken 28 patients, 14 in each group. Results: Parameters like SvO2, HR, SBP, DBP, MAP, PAWP, blood lactate levels were better controlled in Group A than B intraoperatively as well as postoperatively. Conclusion: We conclude that there is better myocardial consumption and supply balance and improved tissue perfusion as measured by SvO2 in patients receiving HTEA in conjunction with general anesthesia as compared in general anesthesia with conventional opioids.