Introduction: Laryngoscopy and endotracheal intubation result in pressor and sympathoadrenal responses. Certain agents such as Lignocaine and Labetalol can be given to prevent these hemodynamic changes prior to intubation. Materials and Methods: 60 patients of ASA grade I, scheduled for various surgeries under general anaesthesia were divided into 2 Groups. Patients in Group A were given 2% Inj. Lignocaine hydrochloride (preservative free) intravenously at 1.5mg/kg over 10 seconds, 90 seconds before laryngoscopy. Patients in Group B were administered 0.5 mg/kg Inj. Labetalol IV, 10 minutes before intubation. Laryngoscopy and endotracheal intubation were performed after induction. Heart rate, systolic, diastolic and the mean arterial blood pressure were recorded before induction, after induction, during intubation and at 1, 3 and 5 minutes post intubation