Background: In this study, we wanted to compare hemodynamic changes in patients receiving dexmedetomidine with those of patients receiving placebo. Materials and methods: This was a hospital based randomized prospective comparative study conducted among 60 patients who presented to the Department of General Anaesthesia in Seth G S Medical College, KEM Hospital Mumbai from 2013 to 2014 after obtaining clearance from Institutional Ethics Committee and written informed consent from the study participants