Aim: The aim of the study is to compare post-operative analgesic efficacy of 0.25% bupivacaine vs 0.25% bupivacaine with dexmedetomidine in transversus abdominis plane block for postoperative caesarean section. Methodology: Prospective randomized double blinded experimental study was conducted among 60 patients posted for elective caesarean section surgery and were divided into two equal groups. Group B patients received 20ml of 0.25% Bupivacaine and Group BD patients received 20ml of 0.25% Bupivacaine with 50 mcg Dexmedetomidine. Visual Analogue Score was used to determine the pain at rest during postoperative period. The time of requirement of rescue analgesia during postoperative period was also assessed.