Background: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Chemical peeling is a documented option in the treatment of active acne. Glycolic acid belongs to the group of α-hydroxy acids is used as a superficial or medium depth peel in acne treatment Jessner’s solution (JS) peel is formulated by Dr. Max Jessner to minimize complication from resorcinol, namely contact dermatitis. Salicylic acid also decreases in inflammatory lesions. Aim of the Study: This study aimed to compare the efficacy and adverse effects of buffered glycolic acid 50% +0.5% salicylic acid solution versus jessner's solution in treatment of mild and moderate acne vulgaris. Patients and Methods: The study included 30 patients with mild to moderate degree acne vulgaris, they were collected from Zagazig university outpatient clinic of dermatology, venerology and andrology from January 2020 to September 2020 after approval of the Institutional Review Board (IRB) number 5831.Twenty four patients completed this study and 6 patients did not complete the study. Patient face was devided into left and right treated sides ,the left side was treated by buffered 50% glycolic acid (ph 3) + 0.5% salicylic acid solution and the right side was treated by jessner's solution.