Aim To observe the efficacy of autologous PRP and phenytoin sodium powder in the healing of non healing ulcer. Material & methods This prospective randomized controlled study included Sample size of 90 patients ( at least 30 in each group). Patients of all age groups with non healing ulcers of more than 3 months duration, irrespective of its aetiology. Debridement of dead necrotic tissue which was done every week after opening the dressing before measuring ulcer size.Every ulcer was tested for culture & sensitivity & treated with specific antibiotics before specific interventions were applied. The patients were randomly allocated to one of the three groups as per their presentation first patient in A, second in B, third in C, fourth again in A, fifth in B & so on.