Introduction: Supraclavicular brachial plexus block could be an alternative and provide comparable effective anaesthesia and postoperative analgesia for shoulder surgery. Interscalene brachial plexus blockade is the standard nerve block for analgesia after arthroscopic and open shoulder surgery. Material and Methods: This is a Prospective, observational and descriptive study conducted in the Department of Anaesthesia at Nimra Institute of Medical Sciences (NIMS) over a period of 1 year. These patients were divided into two groups by simple random method; the patients were divided into group IRD (interscalene block using 30 ml of ropivacaine 0.5% + 50 µg of dexmedetomidine) and another group (supraclavicular block using 30 ml of ropivacaine 0.5% + 50 µg of dexmedetomidine). The procedure was conducted using nerve stimulator technique. Results: The mean time of the onset of sensory block in supraclavicular group was 3.50±0.83, in interscalene was 3.1±0.62 and onset of motor block (min) was 3.60±0.62 in supraclavicular group, in interscalene was 3.21±0.54. The duration of sensory block was 495.53±49.41 min and 759.42±84.15 min in supraclavicular group and interscalene block respectively. Moreover, duration motor block (min) in supraclavicular group was 438.52±47.32, in interscalene was 659.23±38.74. Conclusions: The onset of sensory and motor block was significantly faster in interscalene techniques then supraclavicular. Prolonged duration of sensory and motor block followed by interscalene and supraclavicular approaches, respectively.