Aim: The purpose of the present research was to explore this biologic approach to treat OA, analysing and comparing results of hyaluronic acid (HA) versus platelet-rich plasma (PRP). Methodology: A prospective study with randomised selection of 47 ( 80 knees) patients for the assessment of outcome of treatment of early Osteoarthrosis of knee with intraarticular infiltration of platelet rich plasma (PRP) versus hyaluronic acid (HA) was carried out in the department of orthopaedics at Jawaharlal Nehru Medical College & Acharya Vinoba Bhave Rural Hospital, Sawangi (M), Wardha from July 2012 to April 2014. The patients were grouped into two categories- where 40 knees were injected with intra-articular HA injections and rest was injected with PRP injections. The mean was compared using paired t- test or independent t- test depending on the distribution of samples. The proportions were analysed using Binominal and Chi Square Test.