AIM: To study the efficacy of steroid nasal spray alone and steroid nasal spray with oral steroids in patients of ethmoidal polyposis with chronic rhinosinusitis. MATERIALS AND METHODS: All the patients with presentation of chronic sinusitis with ethmoidal polyposis, fitting in the definition of the study and fulfilling the inclusion criteria had a detailed history taking of the concerned complaints. Steroid therapy was given to each patient in the study for 6 weeks. One group of patients were given topical steroid in form of mometasone nasal spray for 6 weeks (Group A) and the other group was given mometasone nasal spray along with 8 mg of methylprednisolone for 15 days in a tapering dose (Group B). Each patient underwent a thorough radiological examination of the nose following steroid therapy.