Objective: The aim of our study is to compare the relationship between serum FSH and AMH in infertile women and to observe their relationship with antral follicle count ,so as to determine which is a better predictor of infertility Materials and Methods: This study includes 75 infertile women in age group 25-40 years. Blood samples were taken at day three for serum AMH and FSH levels, and AFC was done. AMH was estimated again on day 14 of the menstrual cycle. Results: Mean serum AMH and FSH were 1.18 ± 0.57 ng/ml and 9.09 ± 2.51 mIU/ml on day three of menstrual cycle. Mean AMH levels on day fourteen was 1.12 ± 0.53 ng/ml, which was not significantly different from day three AMH level. There was a significant inverse relationship between serum AMH and FSH concentration (r = −0.488, P < 0.001). Moreover, there was a positive correlation between AMH and AFC (r = 0.641, P < 0.001). Conclusion: There was a significant inverse correlation between serum AMH and FSH levels in infertile women. AMH is considered by us as a better predictor of ovarian reserve because it is relatively stable throughout the cycle. Furthermore, there was positive correlation between AMH and AFC.It denotes reduction of AMH levels in serum is the first indication of a decline in the follicular reserve.