Aim: The study aimed to evaluate and compare the effect of two cavity disinfectants [Chlorhexidine Digluconate 2% and Octenidine Dihydrochloride 0.1%] on the microtensile bond strength at the resin-dentine interface and to observe modes of failures under Scanning Electron Microscope. (SEM) Methods: 21 freshly extracted human permanent molars were sectioned with a doublesided diamond disc to expose mid-coronal dentine and were randomly divided into 3 groups: A, B and C. 7 flat dentine surface were then treated with 37% phosphoric acid gel for 15 seconds. All restored teeth then were thermocycled and longitudinally sectioned and were subjected to micro-tensile testing, and fractured specimens were observed under SEM. Results: There was a statistically significant difference between Group A (Control) and Group C (OCT) in microtensile bond strength. (p<0.05) The difference was no statistically significant between Group A (Control) and Group B (CHX), Group B (CHX) and Group C (OCT). Conclusion: The use of Octenidine Dihydrochloride 0.1% and Chlorhexidine Digluconate 2% solutions after etching the dentine enhanced micro-tensile bond strength of composite restorations.