INTRODUCTION: Oral environment promotes corrosion of metallic components of orthodontic appliance, which leads to release of metals from metallic component causing relevant health threat. AIM: This study is planned to evaluate and compare the release of metal ions from NiTi and Titanium Molybdenum Alloy (TMA) Orthodontic arch wire. MATERIAL AND METHOD: 10 wires each of NiTi and TMA will be incubated in simulated oral environment in artificial saliva for 90 days. After incubation, artificial saliva will be collected and subjected to analytical procedure using Atomic Absorption Spectrophotometer. Data will be subjected to statistical analysis. RESULTS: The metals released from both orthodontic arch wires will be assessed. As the ickel content in NiTi orthodontic arch wire is more, release of nickel may be more causing toxic effects if the patient is allergic to Nickel. CONCLUSION: Metals released from both NiTi and TMA orthodontic arch wires will be accessed and the safer wire will be preferred.