Background: Nishamalaki or Nisha Amalaki representing various combination formulations of Turmeric and Indian gooseberry is recommended in Ayurveda, proven efficacious and widely practiced in the management and prevention of complications of Madhumeha (Diabetes). Aims: To assess the effectiveness of scaling and root planing on the glycemic status and gingival crevicular fluid (GCF) levels of Malondialdehyde, Superoxide Dismutase, Catalase and Osteocalcin in Type II diabetes patients with chronic periodontitis under systemic administration of Nishamalaki, an ayurvedic hypoglycemic formulation. Material and methods: The study included 90 newly diagnosed Type II diabetic patients in the age group between 30 to 50 years with mild to moderate chronic periodontitis and was randomly divided into 45 patients of two groups each. Group A were Type II diabetic patients with mild to moderate chronic periodontitis taking supplements of Nishamalaki 1 gram twice daily for 3 months and Group B were Type II diabetic patients with mild to moderate chronic periodontitis undergoing scaling and root planing and receiving supplements of Nishamalaki 1 gram twice daily for 3 months. Results: Independent t-test has been applied to compare the two groups. It has been observed there is no significant difference exists between the two groups. However administration of Nishamalaki and scaling has been all effective in group B parameters. Conclusion: Nishamalaki showed protective effect and appeared to be useful in reducing the glycemic status, levels of superoxide dismutase, catalase, lipid peroxidase and osteocalcin in GCF in type-2 diabetes patients with chronic periodontitis.