ABSTRACT: Aim: To evaluate and compare the clinical efficacy of subgingivally delivered curcumin gel and hexigel as an adjunct to scaling and root planing in chronic periodontitis patients. Materials and method:A total of 12 subjects of age 18-55years were randomly selected for the study from the Out Patient Department. A total of 36 sites with pocket depths ≥5 mm were chosen as a split mouth design at three different sites in the same patient. After scaling and root planning, in Group I -2% curcumin gel, in Group IIChlorhexidinegel(Hexigel ) and in Group III-placebo gel (control)was placed subgingivally. Clinical parameters such as gingival index and plaque index were recorded at baseline, 7 days and 21 days. Pocket depth was checked at baseline, 21 and 45 days. Results:All the groups showed statistically significant reduction in gingival, plaque indices and pocket depth. Group I(curcumin)as a local delivery agent showedcomparable results in terms of pocket depth reduction as group II (Hexigel). Conclusion:Curcumin gel showed effective results and thus, can be used as an alternate to chlorhexidine gel in management of chronic periodontitis patient without any side effects.