Aim Purpose of our research was to compare and analyze the efficacy of sedation regimens frequently used in dentistry by intravenous approach. Methodology A total of 50 patients were provided one of four treatments: placebo; midazolam provided (mean dose, 8.6 milligrams); fentanyl (1.4 micrograms/kilogram) plus midazolam to get similar amount of sedation (mean dose, 5.7 mg); or fentanyl (1.4 (μg/kg), midazolam (mean dose, 5.8 mg) and methohexital (mean dose, 61.0 mg) used in the surgery. Results Each drug regimen decreased anxiety during surgery when compared with placebo, with the combination of midazolam, fentanyl and methohexital resulting in drastically less anxiety in as compared to other treatment groups. Pain felt by patients during surgery decreased significantly by the combination of fentanyl, midazolam and methohexital. Conclusion It was observed that drugs and doses evaluated resulted in therapeutic benefit for patients undergoing dental procedures, with less possibility of potentially serious adverse effects.