Background: Diabetes is a universal problem and is becoming a major concern at old age especially in obese people and in people with sedentary life style. The present study was conducted to assess complications and mortality in ST-segment elevation acute myocardial infarction in diabetic and non-diabetic patients. Materials & Methods:160 consecutive patients of diabetic (group I) and non-diabetic (group II) having acute ST-segment elevation myocardial infarction (STEMI) of both genders were included. Treatment was given to all patients. Results: Age group <44 years had 15 diabetic and 10 non- diabetic, 45-54 years had 25 diabetic and 12 non- diabetic, 55-64 years had 10 diabetic and 20 non- diabetic and >65 years had 40 diabetic and 28 non- diabetics. The site was anterior in 26 and 20, inferior in 38 and 40, inferior+ right ventricular in 20 and 10 and lateral in 6. Mortality was seen in those in which streptokinase was given in 7 and 3 and streptokinase not given in 15 and 10 in group I and group II respectively (P< 0.05). Conclusion: With streptokinase administration there was reduction in mortality in diabetic as well as in non- diabetic. However, diabetics not on streptokinase had higher mortality as compared to non- diabetics