Background: When compared to laparoscopic surgery, the developing technology of robotic surgery may have some advantages in many challenging endoscopic operations. However, the relative merits of robot-assisted cholecystectomy (RAC) over traditional laparoscopic cholecystectomy (LC) continue to be a contentious topic. This study's objective was to compare RAC and LC for benign gallbladder disease in order to assess their safety and effectiveness. Methods: To find comparative studies evaluating the safety and effectiveness of RAC and LC, a systematic literature search was carried out using the PubMed, EMBASE, and Cochrane Library databases. In addition to utilising R software to analyse the data and apply random effects models, the quality of the literature was evaluated. Results: There were 26 studies total, 3 prospective and 18 retrospective, 5 RCTs, and 21 NRCSs. There were 4004 patients in total, of whom 1833 (46%) underwent RAC and 2171 (54%) underwent LC. There were no appreciable differences between the RAC and LC groups in terms of intraoperative problems, postoperative complications, readmission rate, hospital stay, estimated blood loss, and conversion rate. However, RAC was linked to a longer operating time than LC in the RCT group, which was consistent with the NRCS group (MD = 12.04 min, 95% CI 7.26-16.82); RAC also had a higher rate of incisional hernia in the NRCS group (RR = 3.06, 95% CI 1.42-6.57); and one RCT reported that RAC was comparable to LC (RR = 7.00, 95% CI 0.38-129. Conclusion: For benign gallbladder illnesses, the RAC was not proven to be more efficient or safe than LC, indicating that RAC is a developing treatment rather than immediately taking the place of LC. The existing evidence supports the use of LC in cholecystectomy despite the greater expenses.