Background & Aim: Most of the early kidney diseases do not represent any clinical symptoms therefore left undetected. Chronic kidney disease is characteristically identified by usual testing of blood serum. Advanced cases of chronic kidney disease also manifest with some peculiar symptoms fatigue, loss of appetite, nausea, vomiting, metallic taste, inadvertent weight loss. This study was conducted to compare and correlate various clinical parameters in chronic kidney disease patients with or without hemodialysis. Materials and Methods: The study was conducted over a year time on 80 chronic kidney disease patients. 45 male and 35 female patients in the age range of 30 to 50 years were studied in detail. Parameters and factors associated to chronic kidney disease were considered; Serum Cholesterol, Triglycerides, High Density Lipoproteins, Low Density Lipoproteins, Albumin (urine), Creatinine. Albumin is a type of proteins seen in blood normally. Group 1 patients consisted of 40 patients who underwent hemodialysis procedure. Group 2 patients consisted of 40 patients those have not undergone hemodialysis procedure. All data was forwarded for statistical analysis for further investigation and interpretations. P value less than 0.05 was taken as significant. Statistical Analysis & Results: Statistical analysis was done by using software statistical package for the Social Sciences In group 1, mean Serum Cholesterol level was 179.41 (mg/dl) while mean Triglycerides level was 133.26 (mg/dl). P value was highly significant (0.01) for Serum Cholesterol level. In group 2, the mean Serum Cholesterol level was 201.41 (mg/dl) while mean Triglycerides level was 165.36 (mg/dl). P value was highly significant (0.02) for Serum Cholesterol level. Mean Albumin and mean Creatinine was 29.22 and 1.44 respectively. One-way ANOVA analysis of both study groups revealed highly significant p value.