Aim: To compare the effects of drotaverine hydrochloride and epidosin on cervical dilation in active phase of labour in primigravida. Objectives: 1. To study the effectiveness of Drotaverine in active labour. 2. To study the effectiveness of Epidosin in active labour. 3. To compare their effects on patients. INTRODUCTION: One of the most significant periods in a woman's life is labour. The length of labour during labour has a significant impact on both maternal and perinatal morbidity. In order to expel the uterine foetus from the intrauterine to the extrauterine environment, labour is a contraction process that aims to produce increasing cervical effacement and dilatation. MATERIALS AND METHODS: A descriptive study with a sample size of 300 patients was conducted in our labour room between October 2020 to may 2022. OBSERVATION AND RESULTS: The patients were divided into 3 groups as follows, Group 1=Control Group Group 2= Received 1 ampoule of Drotaverine Hydrochloride 40 mg intravenously at 2 hourly intervals up to a maximum of 3 doses,starting at 3-4 cms cervical dilatation. Group 3= Received, 1 ampoule of Valethamate bromide 8mg intravenously at hourly intervals up to a maximum of 3 doses, starting at 3-4 cms cervical dilatation. RESULTS:  In our study, it was observed that the majority of the patients belonged to the age group of 23-26 years, followed by 27-30 years. Very few patients were less than 22 years of age.  Drotaverine was seen to decrease the duration of active stage of labour by 27% as compared to Valethamate that decreased it by 24%.  The cervical dilatation in group II was increased by 2.3 cm/hr while in group III it was increased by 1.3 cm/hr. There was a significant increase in rate of cervical dilatation in both the groups.  The mean duration of second phase of labour was 144.23 ± 3.57 minutes in Group I, 102.42 ± 1.75 minutes in Group II and 116.56± 2.34 minutes in Group III  The mean injection delivery interval was found to be 101.58±78.06 mins in Drotaverine Group and 134.24±94.12 mins in Valethamate Group.1  Maternal complications like Dryness of mouth,Tachycardia,Vomiting were noted in a few cases.  Drotaverine hydrochloride is a superior cervical dilatation agent than Valethamate bromide in significantly reducing the duration of labor with fewer side effects on the mother or the fetus (17).  Drotaverine hydrochloride and valethamate bromide are better labor accelerators. But drotaverine accelerates labor better than valethemate. The reduction of pain during labor is better with drotaverine than valethamate.