Background: Laparoscopic appendectomy (LA) is now the standard of management for cases of acute appendicitis. LA has the benefits of minimal access surgery. There are many methods for securing the base of the appendix, some of which are expensive others are not available or technically demanding. This study is aimed to compare between ligation and clipping techniques regarding fesibility , safety , efficacy, operative time , postoperative outcome and complications. Patients and methods: A randomized prospective clinical trial study included 90 patients with acute appendicitis. The patients were randomly distributed into 2 main groups (A&B): 54 patients we secured the base of the appendix by ligation methods (group A) and in 36 patients by clip application (group B). All patients were subjected to classic history taking and clinical examination. Radiological investigation: ultrasonography was routinely done for all patients. CT with contrast was requested when indicated in suspicion of complications. Surgical ligation or clipping were performed. Results: There is statistically non-significant difference between patients underwent different surgical techniques as regarding application of peritoneal drainor conversion to open. Two patients within ligation group (A) had been converted to open due to presence of friable base in one case and intraoperative bleeding in other case while three patients within clipping group (B) had been converted to open due to intestinal injury, friable base and intra-operative bleeding .Two cases in clipping group (B) had been converted to ligation techniques due to very wide base which can't be secured by clip application. Conclusion: Ligation and clipping techniques were effective, safe ,feasible and same in complications rate. Clip application is related to less operative time , easier application and simpler for trainee than ligation techniques which require more experiences.