ABSTRACT:Background: The present study was conducted to evaluate clinicopathological characteristics of eyelid lesions. Materials & Methods: 104 patients with eyelid lesions of both genders were recruited. Clinical features, indication for biopsy, surgical findings, and pre-excision clinical diagnosis (PECD) were recorded. Histopathological assessment was performed. Results: Common eye lid lesions were chalazion in 30, sweat gland hidrocystoma in 25, skin tag and wart in 15, epidermal and epidermal inclusion cyst in 9, eyelid nevus in 5, seborrheic keratosis in 3, xanthelasma in 2, molluscum contagiosum in 1, capillary hemangioma in 1, foreign body granuloma in 1 case, malignant melanoma in 3, squamous cell carcinoma in 6, sebaceous carcinoma in 2 and basal cell carcinoma in 1 case.. In 9 cases histopathological diagnosis was different from clinical diagnosis. It was found to be pilomatrixoma in 2 cases, steatocystoma in 2, hemangioendothelioma in 1, seborrheic keratosis in 3 and juvenile xanthogranuloma in 1 case. The difference was significant (P< 0.05). Conclusion: Common lid lesions were chalazion, sweat gland hidrocystoma, skin tag and wart and epidermal and epidermal inclusion cyst. Most common malignant lesion was squamous cell carcinoma.