Abstract: Background: Leprosy is a chronic granulomatous disease and it manifests in varied clinical forms which can mimic many nonrelated inflammatory diseases. So early and precise diagnosis is very important for adequate and early treatment of disease, thus the study is undertaken to determine the extent to which clinical types are correlated with histopathological aspects, which is extremely crucial in patient management. Aims: To establish histopathological types of leprosy cases on the basis of microscopy, special stain and immunofluorescence and to correlate it with clinical presentations. Materials and Methods: In total 100 patients diagnosed clinically as leprosy were studied. Cases of all age groups were included. Skin biopsy were taken from suspected cases and subjected to H and E stain, fite faraco (FF) stain and immunofluorescence. P value was calculated and kappa statistics was used as a strength of agreement. Results: Clinically maximum 30(30%) of the cases belongs to Borderline tuberculoid (BT) leprosy. The overall correlation of clinical diagnosis with histopathology was seen in 77(77%) cases. The utmost concordance (92.85%) was found in LL patients. By fite faraco staining, 21 cases out of 100 shows positivity and by auramine rhodamine staining 40 cases out of 100 shows positive results. Conclusion: We noticed minor disagreement between clinical and histopathological diagnosis. So rather than using single criteria, other contributory factors like determination of bacillary index using special stain and immunofluorescence must be consider to arrive ultimate diagnosis.