Introduction: Lymphadenopathy is a common clinical problem, usually benign, but malignancy may be associated. To confirm the diagnosis often required a biopsy of lymph nodes. Methods: All patients with cervical lymphadenopathy, more than 4 weeks and size more than 1cm were included in the study and a biopsy were done and sent for histopathological study. Results: Out of total 220 patients, 54.5% (n=120) were males & 45.5% (n=100) were females. The mean age was 38.9±1.02 years & the maximum number of patients were adults (50%). The most common cause of cervical lymphadenopathy was reactive hyperplasia (51.8%) followed by granulomatous infection (17.3%). however, in older adults, carcinoma was also a common cause of cervical lymphadenopathy (40%). Conclusion: The most common histopathological diagnosis of cervical lymph node biopsies in central India were reactive disease and granulomatous infections