Posterior reversible encephalopathy syndrome (PRES) is usually diagnosed according to the presence of typical neuroimage showing vasogenic edema predominately involving the posterior brain area. Present study was aimed to study clinicoradiological profile and outcome of patients with posterior reversible encephalopathy syndrome at our tertiary hospital. Material and Methods: Present study was retrospective, case-record based study, conducted in patients with clinical and imaging features suggestive of PRES. Results: 32 case records were studied. Mean age was 39.8 ± 10.7 years. Male (34.38 %) to female (65.63 %) ratio was 1: 0.52. Common clinical features noted were seizure (71.88 %), headache (68.75 %), altered mental status (59.38 %), vomiting (34.38 %), fever (25 %) & visual impairments (18.75 %). Eclampsia (50 %) was most common etiology for PRES, followed by hypertension (18.75 %), renal diseases (15.63 %), postpartum sepsis (9.38 %), poly-trauma (3.13 %) & cardiac disease (3.13 %). MRI Neuroimaging finding in study were involvement of parieto-occipital lobes (65.63 %), subcortical (46.88 %), frontal lobe (34.38 %), temporal lobe (18.75 %), asymmetric involvement of brain (18.75 %), cerebellum (12.50 %), basal ganglia (9.38 %), cortical (9.38 %), subarachnoid bleed (6.25 %), brainstem (3.13 %) & deep white matter (3.13 %), Mortality was observed in 2 cases (6.25 %) (both were antepartum eclampsia, reported to hospital in unconscious state & required intubation on admission). Good prognosis was noted in 30 cases (93.75 %). Conclusion: Early recognition of PRES is associated with good prognosis & good recovery, particularly if underlying etiology is treated satisfactorily.