aediatric Patients in Bihar region. Material and methods: A prospective observational study was conducted in the Department of Paediatrics, Nalanda Medical College and Hospital, Patna, Bihar, India for 14 months. Total 110 Children aged below 18 years with history of fever of more than 7-10 days duration were included in this study. In each case, age, sex, presenting complaint, laboratory investigations and antibiotic sensitivity pattern are collected and analysed. Results: Out of 110 cases, 75 cases (68.18%) were males and 35 cases (31.82%) were females. Most of the cases were aged between 6 and 12 years (50%). The most common symptom was fever (100%), followed by anorexia (64.55%), vomiting (48.18%), pain abdomen (19.09%), diarrhea (13.64%), headache (11.82%), and cough (8.18%). The most common sign we observed was toxic look in 70.90% of the cases followed by coated tongue in 50.90%, hepatomegaly 44.55%, splenomegaly 20.90%, hepatosplenomegaly in 12.73% of cases and pallor in 7.27% of cases. Table 6 depicts the laboratory parameters. Anemia found in 23 (20.90%) cases, leucopenia and leucocytosis was observed in 39(35.45%) cases and 16(14.55%) cases respectively. Neutropenia found in 45(40.90%) cases and neutrophilia was found in 30(27.27%) cases. Eosinopenia was seen in 51(46.36%) cases, eosinophilia in 7(6.36%) cases and thrombocytopenia in 18(16.36%) cases. SGOT levels was elevated (>200IU/ml) in 17(15.45%) cases and SGPT (>200IU/ml) in 15(13.63%) cases. There were no complications observed during our study period. Salmonella typhi O titres >1:100 was seen in 103(93.63%) cases and TH titres >1:200 in 82(74.54%) cases. Blood culture positive for Salmonella typhi noted in 27(24.55%) cases. The most common sensitivity was seen in all the cases ceftriaxone (94%) and followed by cefixime(92%) , ofloxacin (90%), ciprofloxacin (81%), chloramphenicol (78%), cefotaxime (75%),amoxicillin (59%) and azithromycin in (46%). S. typhi was more sensitive to ceftriaxone, cefixime followed by ofloxacin. Least sensitivity was seen with azithromycin. Conclusion: Typhoid fever is most commonly observed with unhygienic practices and eating of unhealthy outside food. This major public health issue can be tackled by bringing awareness among people regarding disease transmission and its various preventive measures.