Various possible and non-mutually exclusive mechanisms may play a role in the development of ischemic stroke in patients with COVID-19. Long duration of mechanical ventilation (ALV) makes patients with COVID-19 who require invasive respiratory support more vulnerable to complications associated with the development of critical illness, including the risk of hypotension and inadequate cerebral perfusion; risk of relative hypertension leading to posterior reversible encephalopathy syndrome; the possibility of septic embolism in the event of a bacterial infection; the possibility of cardiomyopathy and a concomitant decrease in the left ventricular ejection fraction.