INTRODUCTION: AIM: correlation of clinical profile and hypothyroidism in female patients at Nagpur region MATERIAL:This was a cross-sectional study. 220 females’ patients of hypothyroidism attending fromMedicine OPD and IPD were selected for the present study during Dec 2019 to Nov 2020. Demographic details of patientswere recorded for age. Clinical history of patients was noted in detail and their general examination was conducted. RESULT:On basis of symptoms as per age group.Weight gain was more prevalent in patients within age group of 26-30 followed by age group of 36-40 and the numbers were less below 20 age group. Dry skin was found more in age group of 26-30 and 55 and above patients, only 3 patients within age group of 30 -40 were found to have constipation. Cold intolerance was seen in patients within age group of 26-30, 31-35 and 46-50. Depression was more common between age group of (31-35) followed by (21-25) & (41-45). Menstrual problem was common between age group of (21-25) followed by (26-30) and few cases was only seen in age group below 20 and age group of (41-45). Dyspnoea was common in age group above 55. Levels of T3 were high between ae group of (41-45) followed by age group above 50 and decreased in between age group of (46-50). T4 level was high between age group of (36-40) followed by (26- 30) and low between age group of (21-25). TSH level was increased in cases with age group above 50, followed byage group of(31-35)& (21-25) lowered between age group of (46-50). Level of TCH was increased in age group above 50 and lowered between age group of below 20. Triglycerides levels was increased between age group of (41-45) and decreased between age group below 20. HDL levels were found to be decreased with increasing age as it was decreased in age above 50 as compared to age below 20. ONCLUSION:Weight gain may directly be associated with hypothyroidism as Thyroid hormone regulates metabolism in both animals and humans. Present findings reveal old age is more affected. Any patient presenting with weight gain, dry skin,dyspnoea, constipation, cold intolerance, depression, menstrual abnormalities should be suspected of hypothyroidism